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VX-809 biochemical product blog

Tags: Biochemical; VX-809; VX-809 biochemical;

     The VX-809 n/a (Catalog #MBS842972) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:


Please refer to the product datasheet for known applications of a given biochemical. We\'ve tested the VX-809 with the following immunoassay(s):
Structure
Structure VX-809.

Background: VX-809 is a novel CFTR corrector that modulates the folding and trafficking of CFTR protein. VX-809 stabilizes an N-terminal domain in CFTR that contains only MSD1 (membrane-spanning domain 1) and efficaciously restores function to CFTR forms that have missense mutations in MSD1. The action of VX-809 on MSD1 appears to suppress folding defects in F508del-CFTR by enhancing interactions among the NBD1, MSD1, and MSD2 domains.

CAS Number: 936727-05-8
Structure Available?: Yes
Salt Form: No
Cell-Permeable?: Yes
PubChem CID: 16678941. Solubility/Reconstitution Instructions: DMSO (>90 mg/ml)
SMILES: CC1=C(N=C(C=C1)NC(=O)C2(CC2)C3=CC4=C(C=C3)OC(O4)(F)F)C5=CC(=CC=C5)C(=O)O
InChi: InChI=1S/C24H18F2N2O5/c1-13-5-8-19(27-20(13)14-3-2-4-15(11-14)21(29)30)28-22(31)23(9-10-23)16-6-7-17-18(12-16)33-24(25,26)32-17/h2-8,11-12H,9-10H2,1H3,(H,29,30)(H,27,28,31)
InChi Key: UFSKUSARDNFIRC-UHFFFAOYSA-N
Handling: Protect from air and light.
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