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SB1518 (Pacritinib) biochemical product blog

Tags: Biochemical; SB1518 (Pacritinib); SB1518 (Pacritinib) biochemical;

     The SB1518 (Pacritinib) n/a (Catalog #MBS843309) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:


Please refer to the product datasheet for known applications of a given biochemical. We\'ve tested the SB1518 (Pacritinib) with the following immunoassay(s):
Structure
Structure SB1518 (Pacritinib).

Background: A potent JAK2/FLT3 inhibitor. Displays equipotent activity against JAK2 (I?? = 23 nM) and FLT3 (IC?? = 22 nM). SB1518 displays potent anti-proliferative effects on myeloid and lymphoid cell lines driven by mutant or wild-type JAK2 or FLT3, resulting from cell cycle arrest and induction of apoptosis.

CAS Number: 937272-79-2
Structure Available?: Yes
Salt Form: No
Cell-Permeable?: Yes
PubChem CID: 46216796. Solubility/Reconstitution Instructions: DMSO
SMILES: C1CCN(C1)CCOC2=C3COCC=CCOCC4=CC=CC(=C4)C5=NC(=NC=C5)NC(=C3)C=C2
InChi: InChI=1S/C28H32N4O3/c1-2-13-32(12-1)14-17-35-27-9-8-25-19-24(27)21-34-16-4-3-15-33-20-22-6-5-7-23(18-22)26-10-11-29-28(30-25)31-26/h3-11,18-19H,1-2,12-17,20-21H2,(H,29,30,31)/b4-3+
InChi Key: HWXVIOGONBBTBY-ONEGZZNKSA-N
Handling: Protect from air and light.
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