NSC-687852, UCHL5 inhibitor biochemical product blogThe NSC-687852, UCHL5 inhibitor n/a (Catalog #MBS6017748) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below:
3,5-bis[(4 -nitrophen yl)methyli dene]-1-pr op-2-enoyl piperidin- 4-one.
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NSC-687852, UCHL5 inhibitor (3,5-bis[(4-nitrophenyl)methylidene]-1-prop-2-enoylpiperidin-4-one, (3E,5E)-3,5-bis[(4-nitrophenyl)methylene]-1-prop-2-enoyl-piperidin-4-one, b-AP15)
Cell-permeable. Abrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) resulting in accumulation of polyubiquitin in cells. NSC-687852 induces tumor cell apoptosis and tumor progression in four different solid tumor models in vivo.
Molecular Formula: C22H17N3O6. Solubility: DMSO (~35mg/ml).