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LDE-225 biochemical product blog

Tags: Biochemical; LDE-225; LDE-225 biochemical;

     The LDE-225 n/a (Catalog #MBS842366) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:


Please refer to the product datasheet for known applications of a given biochemical. We\'ve tested the LDE-225 with the following immunoassay(s):
Structure
Structure LDE-225.

Background: LDE225 is a potent and selective antagonist of Smoothened (Smo) with IC?? values of 2.5 nM and 1.3 nM for human and mouse Hedgehog, respectively. LDE-225 induces dose-related inhibition of Hh and Smo-dependent tumour growth.

CAS Number: 956697-53-3
Structure Available?: Yes
Salt Form: No
Cell-Permeable?: yes
PubChem CID: 24775005. Solubility/Reconstitution Instructions: DMSO (~5 mg/ml)
SMILES: CC1CN(CC(O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F
InChi: InChI=1S/C26H26F3N3O3/c1-16-14-32(15-17(2)34-16)24-12-9-20(13-30-24)31-25(33)23-6-4-5-22(18(23)3)19-7-10-21(11-8-19)35-26(27,28)29/h4-13,16-17H,14-15H2,1-3H3,(H,31,33)/t16-,17+
InChi Key: VZZJRYRQSPEMTK-CALCHBBNSA-N
Handling: Protect from air and light.
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