• Call +1.858.633.0165 or Fax +1.858.633.0166 or Contact Us

IWP-4 biochemical product blog

Tags: Biochemical; IWP-4; IWP-4 biochemical;

     The IWP-4 n/a (Catalog #MBS842840) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Please refer to the product datasheet for known applications of a given biochemical. We\'ve tested the IWP-4 with the following immunoassay(s):
Structure IWP-4.

Background: IWP-4 is a potent inhibitor of Wnt production that blocks Wnt pathway activity in vitro (IC?? = 25 nM). IWP-4 inactivates Porcupine (porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. At 5 muM, IWP-4 has been shown to block Wnt-dependent phosphorylation of the low-density lipoprotein receptor-related protein 6 receptor and the scaffold protein Dishevelled, preventing the accumulation of beta-catenin. IWP-4 has been used to induce cardiomyocyte differentiation from human pluripotent stem cells.

CAS Number: 686772-17-8
Structure Available?: Yes
Salt Form: No
Cell-Permeable?: Yes. Solubility/Reconstitution Instructions: DMSO (~2 mg/ml)
InChi: InChI=1S/C23H20N4O3S3/c1-13-7-8-14-18(11-13)33-22(24-14)26-19(28)12-32-23-25-15-9-10-31-20(15)21(29)27(23)16-5-3-4-6-17(16)30-2/h3-8,11H,9-10,12H2,1-2H3,(H,24,26,28)
Handling: Protect from air and light.
Request a Quote

Please fill out the form below and our representative will get back to you shortly.

1146 - Table 'mbsds_xtra.countries' doesn't exist

select countries_id, countries_name from countries order by countries_name