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XL019 biochemical product blog

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Posted on 2018-01-09 13:36:04 by mybiosource_staff
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Tags: Biochemical; XL019; XL019 biochemical;
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The XL019 n/a (Catalog #MBS843170) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:


Please refer to the product datasheet for known applications of a given biochemical. We\'ve tested the XL019 with the following immunoassay(s):
Structure
Structure XL019.

Background: XL019 is a potent, highly selective and reversible JAK2 inhibitor (IC?? = 2.2 nM). Inhibits JAK1 (IC?? = 134.3 nM), JAK3 (IC50 = 214.2 nM) and TYK2 (IC?? = 348.3 nM) at higher concentrations. XL019 displays significant dose-dependent pharmacodynamic and antitumor effect in a mouse xenograft model.

CAS Number: 945755-56-6
Structure Available?: Y
Salt Form: No
Cell-Permeable?: Yes
PubChem CID: 57990869. Solubility/Reconstitution Instructions: DMSO (~ 15 mg/ml)
SMILES: C1CC(NC1)C(=O)NC2=CC=C(C=C2)C3=NC(=NC=C3)NC4=CC=C(C=C4)N5CCOCC5
InChi: InChI=1S/C25H28N6O2/c32-24(23-2-1-12-26-23)28-19-5-3-18(4-6-19)22-11-13-27-25(30-22)29-20-7-9-21(10-8-20)31-14-16-33-17-15-31/h3-11,13,23,26H,1-2,12,14-17H2,(H,28,32)(H,27,29,30)/t23-/m0/s1
InChi Key: ISOCDPQFIXDIMS-QHCPKHFHSA-N
Handling: Protect from air and light.
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