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WP1066 biochemical product blog

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Posted on 2018-05-09 13:26:29 by mybiosource_staff
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Tags: Biochemical; WP1066; WP1066 biochemical;
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The WP1066 n/a (Catalog #MBS843246) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:


Background: A potent, cell-permeable JAK2 inhibitor. A novel analog of the JAK2 inhibitor AG490 that blocks STAT3 and phosphoinositide-3-kinase pathways. It is significantly more potent and active against human malignant glioma cells in vitro and in vivo than AG 490. Similar to AG490, WP1066 inhibits the phosphorylation of JAK2, but unlike AG490, WP1066 also degrades JAK2 protein, thus blocking its downstream signal transducer and activator of transcription (STAT) and phosphoinositide-3-kinase pathways to results in the activation of the caspase pathway.

WP1066 n/a

CAS Number: 857064-38-1
Structure Available?: Yes
Salt Form: No
Cell-Permeable?: Yes
MDL Number: MFCD12912450
PubChem CID: 11210478. Solubility/Reconstitution Instructions: DMSO (10 mg/ml) and Ethanol (5 mg/ml)
SMILES: CC(C1=CC=CC=C1)NC(=O)C(=CC2=NC(=CC=C2)Br)C#N
InChi: InChI=1S/C17H14BrN3O/c1-12(13-6-3-2-4-7-13)20-17(22)14(11-19)10-15-8-5-9-16(18)21-15/h2-10,12H,1H3,(H,20,22)/b14-10+/t12-/m0/s1
InChi Key: VFUAJMPDXIRPKO-LQELWAHVSA-N
Handling: Protect from air and light.
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