Antibody Protein ELISA Kit from MyBioSource header Telephone 1.858.633.0165          
1.855.MyBioSource
Fax 1.858.633.0166    Email sales@mybiosource.com 
tel/fax
menu1 Home Products Ordering Company Help menu7
bottom
   MyBioSource  rightarrow Biochemical Blog  rightarrow Thialysine biochemical  rightarrow LOG IN  rightarrow MY ACCOUNT  rightarrow CART CONTENTS  rightarrow CHECKOUT 
horiz bar
MyBioSource Blogs moreseparator
separator
 • 6- Bromotubercidin (8- Bromo- 7- deazaadenosine, 6-Br-Tu) biochemical blog
 • Furagin biochemical blog
 • 2-(5-Bromo-2-formylphenoxy)acetic Acid Ethyl Ester biochemical blog
 • 3 beta-O-Acetyl-androsta-5,15-dien-17-one biochemical blog
 • Didesmethyl Almotriptan biochemical blog
 • 2,3,4,6-Tetra-O-trimethylsilyl-N-(beta-D-galactopyranosyl)-N'-[(2-methanethiosulfonyl)ethyl]urea biochemical blog
 • 2'-Hydroxyacetophenone-d4 Oxime biochemical blog
 • 3-Benzyloxy-4-methoxy-b-nitrostyrene biochemical blog
 • Azumolene Sodium Salt biochemical blog
 • Peroxidase, Horseradish biochemical blog
 • Benzidine, 95% biochemical blog
 • Clofedanol Hydrochloride biochemical blog
 • {[(1S,2R)-1-Benzyl-2-hydroxy-3-[isobutyl-(4-nitro-benzenesulfonyl)-amino]-propyl}-carbamic Acid, tert-butyl Ester biochemical blog
 • 10-Aminodecylmethanethiosulfonate, Hydrobromide biochemical blog
 • (S,R)-N-(1-Phenylethyl) Ibuprofen Amide biochemical blog
 • 4 alpha-Hydroxy Cholesterol biochemical blog
 • N-Stearoyl Phytosphingosine biochemical blog
 • Candesartan biochemical blog
 • Ethyl 4,6-(4-Methoxybenzylidene)-b-D-thiogalactopyranoside biochemical blog
 • Meclofenoxate Hydrochloride biochemical blog
separator
Blog Categories separator
separator
 • Assay Kit Blogs
 • Biochemical Blogs
 • cDNA Clone Blogs
 • Monoclonal Antibody Blogs
 • Polyclonal Antibody Blogs
 • Rec/Purified Protein Blogs
 • Popular Product Blogs
separator
Our Best Sellers moreseparator
separator
 • CD32a (FcgRIIa) Recombinant Protein
 • lipase A, lysosomal acid, cholesterol esterase ELISA Kit
 • HBB Antibody
 • Lamina-associated polypeptide 2, isoform alpha (TMPO) Recombinant Protein
 • LEPR ELISA Kit
 • DCPS Recombinant Protein
 • Inducible nitric oxide synthase (iNOS) ELISA Kit
 • R-spondin family, member 4 (RSPO4) ELISA Kit
 • Apolipoprotein CIII (Apo CIII) Antibody
 • CD21  Antibody
 • heparin-binding EGF-like growth factor (HBEGF) ELISA Kit
 • CKLFSF5 ELISA Kit
 • Total Bilirubin (TBIL) ELISA Kit
 • Coagulation Factor IX (F9) ELISA Kit
 downarrow more ...
separator

Thialysine biochemical product blog

separator
Posted on 2016-01-12 17:22:12 by mybiosource_staff
Share it on ...     
separator
separator
Tags: Biochemical; Thialysine; Thialysine biochemical;
separator
The Thialysine n/a (Catalog #MBS6088111) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:


The lysine analog, thialysine, has been implicated in the mechanism for the inhibitory effect of the on human acute leukemia Jurkat T cells. When Jurkat T cells were treated with thialysine (0.32-2.5mM), apoptotic cell death along with several biochemical events such as mitochondrial cytochrome c release, caspase-9 activation, caspase-3 activation, degradation of poly (ADP-ribose) polymerase, and DNA fragmentation was induced in a dose- and time-dependent manner. However, these thialysine-induced apoptotic events were significantly abrogated by an ectopic expression of Bcl-xL, which is known to block mitochondrial cytochrome c release. Decylubiquinone, a mitochondrial permeability transition pore inhibitor, also suppressed thialysine-induced apoptotic events. Comparison of the thialysine-induced alterations in the cell cycle distribution between Jurkat T cells transfected with Bcl-xL gene (J/Bcl-xL) and Jurkat T cells transfected with vector (J/Neo) revealed that the apoptotic cells were mainly derived from the cells accumulated in S and G2/M phases following thialysine treatment. The interruption of cell cycle progression in the presence of thialysine was accompanied by a significant decline in the protein level of cdk4, cdk6, cdc2, cyclin A, cyclin B1, and cyclin E. These results demonstrate that the cytotoxic activity of thialysine toward Jurkat T cells is attributable to not only apoptotic cell death mediated by a mitochondria-dependent death signaling pathway, but also interruption of cell cycle progression by a massive down-regulation in the level of cdks and cyclins.

Thialysine n/a

CAS Number: 4099-35-8
Molecular Formula: C5H12N2O2S·HCl
Chloride Content: (Titration).
horiz bar
 SSL   Follow us on Facebook Follow us onTwitter Follow us on Google Plus Connect us on LinkedIn Subscribe to our RSS Feed for latest products and special promotions