Tetromycin A biochemical product blog
Tags: Biochemical; Tetromycin A; Tetromycin A biochemical;
The Tetromycin A n/a (Catalog #MBS6110692) is a Biochemical produced from Tetromycin An and is intended for research purposes only. The product is available for immediate purchase.To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Tetromycin An is an unusual tetronic acid structurally related to kijanimicin, chlorothricin, saccharocarcin, tetrocarcin and versipelostatin. Tetromycin A has pronounced activity against antibiotic susceptible and resistant Gram positive bacteria including MRSA. Limited availability has restricted further investigation of this metabolite in the literature. Several members of this class have received considerable literature focus. Versipelostatin was shown to inhibit transcription from the promoter of GRP78, a gene that is activated as part of a stress signalling pathway under glucose deprivation resulting in unfolded protein response (UPR). The UPR-inhibitory action was seen only in conditions of glucose deprivation and caused selective and massive killing of the glucose-deprived cells. Tetrocarcin An appears to target the phosphatidylinositide-3\'- kinase/Akt signalling pathway.
CAS Number: 180027-83-2
Molecular Formula: C36H48O6. Solubility: Soluble in ethanol, methanol, DMF or DMSO. Moderately soluble in water.