TAPI-1 biochemical product blog
Tags: Biochemical; TAPI-1; TAPI-1 biochemical;
The TAPI-1 n/a (Catalog #MBS842463) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase.To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given biochemical. We\'ve tested the TAPI-1 with the following immunoassay(s):
Structure
Background: Inhibitor of TNF-alpha processing (IC?? = 100 nM), similar to TAPI-0, but more stable in tissue culture and in vivo. Inhibits TACE and other metalloproteases. Blocks release of TNF- alpha (IC?? = 50-100 muM), APP (1-8 muM), IL6R (5- 10 muM), TNFRI (5 -10 muM), TNFRII (25 -50 muM), and ObRa (leptin receptor), but not CSF-1, from cells in culture.
CAS Number: 171235-71-5
Structure Available?: Yes
Cell-Permeable?: No
PubChem CID: 9827273. Solubility/Reconstitution Instructions: DMSO and MEOH
SMILES: CC(C)CC(CC(=O)NO)C(=O)NC(CC1=CC2=CC=CC=C2C=C1)C(=O)NC(C)C(=O)NCCN
InChi: InChI=1S/C26H37N5O5/c1-16(2)12-21(15-23(32)31-36)25(34)30-22(26(35)29-17(3)24(33)28-11-10-27)14-18-8-9-19-6-4-5-7-20(19)13-18/h4-9,13,16-17,21-22,36H,10-12,14-15,27H2,1-3H3,(H,28,33)(H,29,35)(H,30,34)(H,31,32)/t17-,21?,22-/m0/s1
InChi Key: AWNBSWDIOCXWJW-OWHMDLSXSA-N
Handling: Protect from air and moisture.