|The Spautin-1, Autophagy inhibitor n/a (Catalog #MBS6112180) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. The amino acid sequence is listed below:
6-Fluoro-N -(4-fluoro benzyl)qui nozaline-4 -amine.
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Cell-permeable. A specific and potent autophagy inhibitor in mammalian cells. It promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin specific peptidases, USP10 and USP13, that target the Beclin1 subunit of Vps34 complexes. Spautin-1 blocks the prosurvival autophagy pathway in cancer cells.
CAS Number: 1262888-28-7
Molecular Formula: C15H11F2N3. Solubility: DMSO (~100mM).