Smo Antagonist, SA9 biochemical product blog
Tags: Biochemical; Smo Antagonist, SA9; Smo Antagonist, SA9 biochemical;
The Smo Antagonist, SA9 n/a (Catalog #MBS842932) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase.To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given biochemical. We\'ve tested the Smo Antagonist, SA9 with the following immunoassay(s):
Structure
Background: SA9 inhibits Hh pathway by interacting directly with Smo. It inhibits SAG (Smoothened agonist) activation of Hh signaling in Shh-LIGHT 2 cells (IC?? = 19 uM). Induces the localization of Smo to cilia in ASZ1 cells, but not in IMCD3 cells. Also treatment of Ptch1-/- MEFs with SA9 suppresses the beta-galactosidase activity (IC?? = 1.0 uM) and inhibits the expression of Gli1 and Ptch1 in ASZ1 cells.
Structure Available?: Yes
Salt Form: No
Cell-Permeable?: Yes
PubChem CID: 20880974. Solubility/Reconstitution Instructions: DMSO
SMILES: C1CCC(=CC1)CCNC(=O)CCC2=NN=C3N2C4=CC=CC=C4C(=O)N3CC5=CC=C(C=C5)Cl
InChi: InChI=1S/C27H28ClN5O2/c28-21-12-10-20(11-13-21)18-32-26(35)22-8-4-5-9-23(22)33-24(30-31-27(32)33)14-15-25(34)29-17-16-19-6-2-1-3-7-19/h4-6,8-13H,1-3,7,14-18H2,(H,29,34)
InChi Key: YTDIPVZSLXYGNL-UHFFFAOYSA-N
Handling: Protect from air and moisture.