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SIRT2 Inhibitor, AGK2 biochemical product blog

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Posted on 2015-12-01 21:08:33 by mybiosource_staff
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Tags: Biochemical; SIRT2 Inhibitor, AGK2; SIRT2 Inhibitor, AGK2 biochemical;
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The SIRT2 Inhibitor, AGK2 n/a (Catalog #MBS843245) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:


Please refer to the product datasheet for known applications of a given biochemical. We\'ve tested the SIRT2 Inhibitor, AGK2 with the following immunoassay(s):
Structure
Structure SIRT2 Inhibitor, AGK2.

Background: A potent inhibitor of sirtuin 2 (SIRT2) (IC?? = 3.5 uM). AGK2 is >15-fold more selective for SIRT2 than SIRT1 and SIRt3. Inhibition of SIRT2 rescued alpha-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson\'s disease.

CAS Number: 304896-28-4
Structure Available?: Yes
Salt Form: No
Cell-Permeable?: Yes
MDL Number: MFCD01909444
PubChem CID: 2130404. Solubility/Reconstitution Instructions: DMSO
SMILES: C1=CC2=C(C=CC=N2)C(=C1)NC(=O)C(=CC3=CC=C(O3)C4=C(C=CC(=C4)Cl)Cl)C#N
InChi: InChI=1S/C23H13Cl2N3O2/c24-15-6-8-19(25)18(12-15)22-9-7-16(30-22)11-14(13-26)23(29)28-21-5-1-4-20-17(21)3-2-10-27-20/h1-12H,(H,28,29)/b14-11+
InChi Key: SVENPFFEMUOOGK-SDNWHVSQSA-N
Handling: Protect from air and light.
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