SGI-1776 biochemical product blog
Tags: Biochemical; SGI-1776; SGI-1776 biochemical;
The SGI-1776 n/a (Catalog #MBS843212) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase.To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given biochemical. We\'ve tested the SGI-1776 with the following immunoassay(s):
Structure
Background: SGI-1776 is a potent and ATP-competitive Pim kinase inhibitor (IC??\'s = 7, 363, and 69 nM for Pim-1, Pim-2 and Pim-3, respectively). SGI-1776 also inhibits FLT3 (IC?? = 44 nM). Induces apoptosis in chronic lymphocytic leukemia cells.
CAS Number: 1025065-69-3
Structure Available?: Y
Salt Form: No
Cell-Permeable?: Yes
PubChem CID: 24795070. Solubility/Reconstitution Instructions: DMSO (>75 mg/ml)
SMILES: CN1CCC(CC1)CNC2=NN3C(=NC=C3C4=CC(=CC=C4)OC(F)(F)F)C=C2
InChi: InChI=1S/C20H22F3N5O/c1-27-9-7-14(8-10-27)12-24-18-5-6-19-25-13-17(28(19)26-18)15-3-2-4-16(11-15)29-20(21,22)23/h2-6,11,13-14H,7-10,12H2,1H3,(H,24,26)
InChi Key: MHXGEROHKGDZGO-UHFFFAOYSA-N
Handling: Protect from air and light.