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RK-33 biochemical product blog

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Posted on 2018-10-09 23:18:50 by mybiosource_staff
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Tags: Biochemical; RK-33; RK-33 biochemical;
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The RK-33 n/a (Catalog #MBS846413) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:


Please refer to the product datasheet for known applications of a given biochemical. We\'ve tested the RK-33 with the following immunoassay(s):
Structure
Structure RK-33.

RK-33 is an inhibitor of DEAD box 3 (DDX3); an ATP-dependent RNA helicase. RK-33 inhibits the growth of lung cancer cells that overexpress DDX3 (IC50s = 4.4-8.4 uM) but is less effective in cells with low DDX3 expression (IC50 > 25 uM). It also promotes radiation sensitization in cells overexpressing DDX3. RK-33 in combination with radiation induces tumor regression in multiple animal models of lung cancer.

Salt Form: No
Molecular Formula: C23H20N6O3
CAS Number: 1070773-09-9. Cell-Permeable: Yes
Reconstitution: DMSO (>20 mg/ml)
SMILES: COC1=CC=C(C=C1)CN2C=NC3=C2N=CN=C4C3=NC(=O)N4CC5=CC=C(C=C5)OC
InChi: InChI=1S/C23H20N6O3/c1-31-17-7-3-15(4-8-17)11-28-14-26-19-20-22(25-13-24-21(19)28)29(23(30)27-20)12-16-5-9-18(32-2)10-6-16/h3-10,13-14H,11-12H2,1-2H3
InChi Key: COUMZXFUZDBRCZ-UHFFFAOYSA-N.
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