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Regorafenib biochemical product blog

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Posted on 2015-12-17 01:55:48 by mybiosource_staff
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Tags: Biochemical; Regorafenib; Regorafenib biochemical;
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The Regorafenib n/a (Catalog #MBS841984) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:


Please refer to the product datasheet for known applications of a given biochemical. We\'ve tested the Regorafenib with the following immunoassay(s):
Structure
Structure Regorafenib.

Background: Regorafenib is a multi-kinase inhibitor targeting angiogenic (VEGFR, TIE-2), stromal (PDGFR-beta) and oncogenic (RAF, RET and c-KIT) receptor tyrosine kinases, with IC??s of 17, 40 and 69 nM for c-KIT, VEGFR2, B-Raf, respectively. Displays potential antiangiogenic and antineoplastic activities.

CAS Number: 755037-03-7
Structure Available?: Yes
Salt Form: No
Cell-Permeable?: yes
PubChem CID: 11167602. Solubility/Reconstitution Instructions: DMSO (>50 mg/ml)
SMILES: CNC(=O)C1=NC=CC(=C1)OC2=CC(=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F)F
InChi: InChI=1S/C21H15ClF4N4O3/c1-27-19(31)18-10-13(6-7-28-18)33-12-3-5-17(16(23)9-12)30-20(32)29-11-2-4-15(22)14(8-11)21(24,25)26/h2-10H,1H3,(H,27,31)(H2,29,30,32)
InChi Key: FNHKPVJBJVTLMP-UHFFFAOYSA-N
Handling: Protect from air and light.
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