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Quizartinib biochemical product blog

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Posted on 2017-09-09 13:50:58 by mybiosource_staff
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Tags: Biochemical; Quizartinib; Quizartinib biochemical;
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The Quizartinib n/a (Catalog #MBS842816) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:


Please refer to the product datasheet for known applications of a given biochemical. We\'ve tested the Quizartinib with the following immunoassay(s):
Structure
Structure Quizartinib.

Background: Cell-permeable. A second generation FLT3 receptor tyrosine kinase inhibitor. Quizartinib displays high affinity for FLT3 in a binding assay (Kd = 1.6 nM) and is a potent inhibitor in cellular autophosphorylation assays (IC?? = 1.1 nM for FLT3-ITD and 4.2 nM for wt FLT3).  It inhibits the growth of human leukemia cell line MV4-11 (IC??0 = 0.56 nM) which is FLT3 dependent and contains a homozygous FLT3-ITD mutation, and A375 cells (IC50 > 10,000 nM) which are not FLT3 dependent and contain an activating mutation in BRAF. .

CAS Number: 950769-58-1
Structure Available?: Yes
Salt Form: No
Cell-Permeable?: Yes
MDL Number: MFCD18074524
PubChem CID: 24889392. Solubility/Reconstitution Instructions: DMSO (~200 mg/ml)
SMILES: CC(C)(C)C1=CC(=NO1)NC(=O)NC2=CC=C(C=C2)C3=CN4C5=C(C=C(C=C5)OCCN6CCOCC6)SC4=N3
InChi: InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22-18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)
InChi Key: CVWXJKQAOSCOAB-UHFFFAOYSA-N
Handling: Protect from air and light.
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