|The PHA-543613 Dihydrochloride n/a (Catalog #MBS6039885) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase.
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PHA-543613 is a potent selective 7 nAChR agonist. Nicotinic acetylcholine receptors are ligand-gated ion channels activated by nicotine, expressed in multiple tissues, with high functional expression in brain. The homomeric subtype 7 is a potential therapeutic target for cognitive deficits in schizophrenia and Alzheimer s disease. PHA-543613 is active in both in vitro (binding, calcium flux, patch-clamp) and in vivo (auditory gating, novel object recognition) assays.
CAS Number: 478148-58-2
Molecular Formula: C15H19Cl2N3O2. Melting Point: >300 degree C
Solubility: DMSO, Methanol