Neratinib biochemical product blog
Tags: Biochemical; Neratinib; Neratinib biochemical;
The Neratinib n/a (Catalog #MBS842745) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase.To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given biochemical. We\'ve tested the Neratinib with the following immunoassay(s):
Structure
Background: Cell-permeable. A second-generation inhibitor of the ErbB family of receptor kinases. Neratinib acts as an irreversible inhibitor of the epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER-2) tyrosine kinases by targeting a cysteine residue in the ATP-binding site of the receptor. It inhibits the proliferation of HER-2 overexpressing human breast cancer cell lines and EGFR-dependent cells in vitro.�.
CAS Number: 698387-09-6
Structure Available?: Yes
Salt Form: No
Cell-Permeable?: Yes
MDL Number: MFCD09752958
PubChem CID: 9915743. Solubility/Reconstitution Instructions: DMSO (~ 2 mg/ml)
SMILES: CCOC1=C(C=C2C(=C1)N=CC(=C2NC3=CC(=C(C=C3)OCC4=CC=CC=N4)Cl)C#N)NC(=O)C=CCN(C)C
InChi: InChI=1S/C30H29ClN6O3/c1-4-39-28-16-25-23(15-26(28)36-29(38)9-7-13-37(2)3)30(20(17-32)18-34-25)35-21-10-11-27(24(31)14-21)40-19-22-8-5-6-12-33-22/h5-12,14-16,18H,4,13,19H2,1-3H3,(H,34,35)(H,36,38)/b9-7+
InChi Key: JWNPDZNEKVCWMY-VQHVLOKHSA-N
Handling: Protect from air and moisture.