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MK-1439 biochemical product blog

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Posted on 2017-10-09 09:20:05 by mybiosource_staff
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Tags: Biochemical; MK-1439; MK-1439 biochemical;
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The MK-1439 n/a (Catalog #MBS846392) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:


Please refer to the product datasheet for known applications of a given biochemical. We\'ve tested the MK-1439 with the following immunoassay(s):
Structure
Structure MK-1439.

MK-1439 (also known as Doravirine); is a non-reversible reverse transcriptase inhibitor used in the treatment of HIV/AIDS with IC50 values of 12; 9.7; and 9.7 nM against the wild type (WT); K103N and Y181C reverse transcriptase (RT) mutants; respectively. It displays excellent activity of suppressing the replication of WT virus with 95% effective concentration of 20 nM. It also exhibited anti-virus activity against 10 different HIV-1 subtype viruses including K103N; Y81C.

Salt Form: No
CAS Number: 1338225-97-0 . Cell-Permeable: Yes
Reconstitution: DMSO
SMILES: CN1C(=NNC1=O)CN2C=CC(=C(C2=O)OC3=CC(=CC(=C3)C#N)Cl)C(F)(F)F
InChi: InChI=1S/C17H11ClF3N5O3/c1-25-13(23-24-16(25)28)8-26-3-2-12(17(19,20)21)14(15(26)27)29-11-5-9(7-22)4-10(18)6-11/h2-6H,8H2,1H3,(H,24,28)
InChi Key: ZIAOVIPSKUPPQW-UHFFFAOYSA-N.
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