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LDN-57444 biochemical product blog

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Posted on 2016-01-05 23:31:03 by mybiosource_staff
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Tags: Biochemical; LDN-57444; LDN-57444 biochemical;
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The LDN-57444 n/a (Catalog #MBS841982) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:


Please refer to the product datasheet for known applications of a given biochemical. We\'ve tested the LDN-57444 with the following immunoassay(s):
Structure
Structure LDN-57444.

Background: Cell-permeable. LDN-57444 is a potent, reversible, competitive and active site-directed inhibitor of UCHL1 (Ki = 0.4 muM). Decreases proteasome activity and increases levels of ubiquitinated proteins. Induces apoptosis. Causes dramatic alterations in synaptic protein distribution and spine morphology in vivo.

CAS Number: 668467-91-2
Structure Available?: Yes
Salt Form: No
Cell-Permeable?: Yes
MDL Number: MFCD09037562
PubChem CID: 16760696. Solubility/Reconstitution Instructions: DMSO (20 mg/ml)
SMILES: CC(=O)ON=C1C2=C(C=CC(=C2)Cl)N(C1=O)CC3=C(C=CC(=C3)Cl)Cl
InChi: InChI=1S/C17H11Cl3N2O3/c1-9(23)25-21-16-13-7-12(19)3-5-15(13)22(17(16)24)8-10-6-11(18)2-4-14(10)20/h2-7H,8H2,1H3/b21-16-
InChi Key: OPQRFPHLZZPCCH-PGMHBOJBSA-N
Handling: Protect from air and light.
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