JAK Inhibitor, Pyridone 6 biochemical product blog
Tags: Biochemical; JAK Inhibitor, Pyridone 6; JAK Inhibitor, Pyridone 6 biochemical;
The JAK Inhibitor, Pyridone 6 n/a (Catalog #MBS842591) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase.To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given biochemical. We\'ve tested the JAK Inhibitor, Pyridone 6 with the following immunoassay(s):
Structure
Background: Cell-permeable. JAK Inhibitor, Pyridone 6 is a potent, reversible, ATP-competitive JAK inhibitor. It inhibits JAK1, 2, and 3 with IC?? values of 15, 1, and 5 nM, respectively. Displays signi?cantly weaker affinities (IC??s = 130 nM - > 10 muM) for other protein tyrosine kinases. It was shown to block IL-2 and IL-4-dependent proliferation of mouse T-cell lymphoma cells with IC?? values of 50-100 nM.
CAS Number: 457081-03-7
Structure Available?: Yes
Salt Form: No
Cell-Permeable?: Yes
MDL Number: MFCD17019334
PubChem CID: 5494425. Solubility/Reconstitution Instructions: DMSO (5 mg/ml)
SMILES: CC(C)(C)C1=NC2=C(N1)C3=C(C=C(C=C3)F)C4=C2C=CNC4=O
InChi: InChI=1S/C18H16FN3O/c1-18(2,3)17-21-14-10-5-4-9(19)8-12(10)13-11(15(14)22-17)6-7-20-16(13)23/h4-8H,1-3H3,(H,20,23)(H,21,22)
InChi Key: VNDWQCSOSCCWIP-UHFFFAOYSA-N
Handling: Protect from air and light.