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HC Toxin biochemical product blog

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Posted on 2016-01-25 04:08:28 by mybiosource_staff
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Tags: Biochemical; HC Toxin; HC Toxin biochemical;
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The HC Toxin n/a (Catalog #MBS842318) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:


Please refer to the product datasheet for known applications of a given biochemical. We\'ve tested the HC Toxin with the following immunoassay(s):
Structure
Structure HC Toxin.

Background: HC Toxin is a cyclic tetrapeptide first isolated from H. carbonum (now C. carbonum), a pathogen of maize. It is a reversible inhibitor of histone deacetylases (HDACs) (IC?? = 30 nM). Through its effects on HDACs, HC toxin has been shown to up-regulate the expression of 15-lipoxygenase-1 in colorectal cancer cells and induce fetal hemoglobin in human primary erythroid cells.

CAS Number: 83209-65-8
Structure Available?: Y
Salt Form: No
Cell-Permeable?: Yes
MDL Number: MFCD00133388
PubChem CID: 23724535. Solubility/Reconstitution Instructions: DMSO
SMILES: O=C(C1CO1)CCCCC[C@@H](C(N2[C@]3([H])CCC2)=O)NC([C@@H](C)NC([C@H](C)NC3=O)=O)=O
InChi: InChI=1S/C21H32N4O6/c1-12-18(27)22-13(2)19(28)24-14(7-4-3-5-9-16(26)17-11-31-17)21(30)25-10-6-8-15(25)20(29)23-12/h12-15,17H,3-11H2,1-2H3,(H,22,27)(H,23,29)(H,24,28)/t12-,13+,14-,15+,17?/m0/s1
InChi Key: GNYCTMYOHGBSBI-KVUCBBCISA-N
Handling: Protect from air and light.
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