|The Guanosine- 3\', 5\'- cyclic monophosphate, acetoxymethyl ester (cGMP-AM) n/a (Catalog #MBS256335) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase.
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Please refer to the product datasheet for known applications of a given biochemical. We\'ve tested the Guanosine- 3\', 5\'- cyclic monophosphate, acetoxymethyl ester (cGMP-AM) with the following immunoassay(s):
C13H16N5O9P; MW 417.3; lambdamax 252 nm; epsilon 13500; purity > 95% HPLC for mixture isomers.
Membrane-permeant precursor of the second messenger cyclic GMP. Metabolic activation by esterases releases the polar active analogue which is trapped inside the cell. In contrast to other membrane-permeant and PDE-resistant cGMP analogues, cGMP-AM yields a transient increase (pulse) of cGMP. Especially suitable for external triggering of cGMP-regulated phosphodiesterases (PDE II, III & V) where most cGMP analogues are not accepted. Detailed technical information available. Reference: Schwede et al., Bioorg. Med. Chem. Lett., 10, 571 - 573 (2000).
Unit Equivalent: 1 umol is approximately equals to 0.4 mg
CAS No.: 164007-71-0. Formula: C13H16N5O9P.