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GSK126 biochemical product blog

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Posted on 2016-03-08 11:00:09 by mybiosource_staff
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Tags: Biochemical; GSK126; GSK126 biochemical;
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The GSK126 n/a (Catalog #MBS842897) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:


Please refer to the product datasheet for known applications of a given biochemical. We\'ve tested the GSK126 with the following immunoassay(s):
Structure
Structure GSK126.

Background: A potent, highly selective, S-adenosyl-methionine(SAM)-competitive, small-molecule inhibitor of EZH2 methyltransferase activity. GSK126 is highly selective against other methyltransferases and multiple other protein classes, even 150-fold more selective for the closest EZH1 (Kiapp = 89 nM) and more than 1,000-fold selective for 20 other human methyltransferases, including both SET-domain-containing and non-SET domain-containing methyltransferases. It decreases global H3K27me3 levels and reactivates silenced polycomb repressive complex 2 (PRC2) target genes.

CAS Number: 1346574-57-9
Structure Available?: Yes
Salt Form: No
Cell-Permeable?: Yes
PubChem CID: 68210102. Solubility/Reconstitution Instructions: DMSO (~50 mg/ml)
SMILES: CCC(C)N1C=C(C2=C(C=C(C=C21)C3=CN=C(C=C3)N4CCNCC4)C(=O)NCC5=C(C=C(NC5=O)C)C)C
InChi: InChI=1S/C31H38N6O2/c1-6-22(5)37-18-20(3)29-25(30(38)34-17-26-19(2)13-21(4)35-31(26)39)14-24(15-27(29)37)23-7-8-28(33-16-23)36-11-9-32-10-12-36/h7-8,13-16,18,22,32H,6,9-12,17H2,1-5H3,(H,34,38)(H,35,39)/t22-/m0/s1
InChi Key: FKSFKBQGSFSOSM-QFIPXVFZSA-N
Handling: Protect from light and moisture.
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