The GSK-J4 hydrochloride n/a (Catalog #MBS842019) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase.
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Please refer to the product datasheet for known applications of a given biochemical. We\'ve tested the GSK-J4 hydrochloride with the following immunoassay(s): Structure
Background: Cell-permeable. An ethyl ester derivative of the JMJD3 selective histone demethylase inhibitor GSK-J1 (IC??> 50 muM in vitro. When administered to human primary macrophages, GSK-J4 can reduce lipopolysaccharide (LPS)-induced proinflammatory cytokine production, most notably including that of TNFalpha (IC?? = 9 uM).
Structure Available?: Yes Salt Form: No Cell-Permeable?: Yes. Solubility/Reconstitution Instructions: DMSO Handling: Protect from light and mositure.