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Garcinol biochemical product blog

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Posted on 2015-09-16 20:06:01 by mybiosource_staff
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Tags: Biochemical; Garcinol; Garcinol biochemical;
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The Garcinol n/a (Catalog #MBS842692) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:


Please refer to the product datasheet for known applications of a given biochemical. We\'ve tested the Garcinol with the following immunoassay(s):
Structure
Structure Garcinol.

Background: Garcinol is a polyisoprenylated benzophenone derivative isolated from Garcinia indica. It is a potent inhibitor of histone acetyltransferases (HATs) p300 (IC50 = 7 uM) and PCAF (IC50 = 5 uM) both in vitro and in vivo. HAT activity-dependent chromatin transcription was inhibited by garcinol, but it had no effect on naked DNA transcription. Moreover, it induces apoptosis in several types of cancer cells and has anti-inflammatory actions. Garcinol promotes neurogenesis and ex vivo expansion of human hematopoietic stem cells.

CAS Number: 78824-30-3
Structure Available?: Yes
Cell-Permeable?: Yes
MDL Number: MFCD03700761
PubChem CID: 3531. Solubility/Reconstitution Instructions: DMSO (25 mg/ml) or EtOH (25 mg/ml)
SMILES: CC(=CCC1CC2(C(=O)C(=C(C3=CC(=C(C=C3)O)O)O)C(=O)C(C2=O)(C1(C)C)CC=C(C)C)CC(CC=C(C)C)C(=C)C)C
InChi: InChI=1S/C38H50O6/c1-22(2)11-13-27(25(7)8)20-37-21-28(15-12-23(3)4)36(9,10)38(35(37)44,18-17-24(5)6)34(43)31(33(37)42)32(41)26-14-16-29(39)30(40)19-26/h11-12,14,16-17,19,27-28,39-41H,7,13,15,18,20-21H2,1-6,8-10H3
InChi Key: DTTONLKLWRTCAB-UHFFFAOYSA-N
Handling: Protect from air and light.
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