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Gambogic acid biochemical product blog

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Posted on 2015-12-29 17:20:45 by mybiosource_staff
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Tags: Biochemical; Gambogic acid; Gambogic acid biochemical;
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The Gambogic acid n/a (Catalog #MBS842410) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:


Please refer to the product datasheet for known applications of a given biochemical. We\'ve tested the Gambogic acid with the following immunoassay(s):
Structure
Structure Gambogic acid.

Background: Gambogic acid is a plant-derived natural product that acts as a caspase activator and apoptosis inducer, which causes an irreversible arrest in the G2/M phase of the cell cycle. It causes a decrease of Bcl-2 gene and an increase in Bax gene expression, which may result in apoptosis. Gambogic also acts as an inhibitor of A1 and Bcl-2 family proteins, including Bcl-xl, Bcl-2, Bcl-w, Bcl-B, Bfl-1, and Mcl-1.

CAS Number: 2752-65-0
Structure Available?: Y
Salt Form: No
Cell-Permeable?: Y
PubChem CID: 9852185. Solubility/Reconstitution Instructions: DMSO (>25 mg/ml) or EtOH (~20 mg/ml)
SMILES: CC(=CCCC1(C=CC2=C(O1)C(=C3C(=C2O)C(=O)C4=CC5CC6C4(O3)C(C5=O)(OC6(C)C)CC=C(C)C(=O)O)CC=C(C)C)C)C
InChi: InChI=1S/C38H44O8/c1-20(2)10-9-15-36(8)16-14-24-29(39)28-30(40)26-18-23-19-27-35(6,7)46-37(33(23)41,17-13-22(5)34(42)43)38(26,27)45-32(28)25(31(24)44-36)12-11-21(3)4/h10-11,13-14,16,18,23,27,39H,9,12,15,17,19H2,1-8H3,(H,42,43)/b22-13-/t23-,27+,36-,37+,38-/m1/s1
InChi Key: GEZHEQNLKAOMCA-RRZNCOCZSA-N
Handling: Protect from air and light.
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