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FK-866 biochemical product blog

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Posted on 2015-08-15 21:58:37 by mybiosource_staff
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Tags: Biochemical; FK-866; FK-866 biochemical;
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The FK-866 n/a (Catalog #MBS841941) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:


Please refer to the product datasheet for known applications of a given biochemical. We\'ve tested the FK-866 with the following immunoassay(s):
Structure
Structure FK-866.

Background: Cell-permeable. FK-866 is a highly specific non-competitive inhibitor of Nicotinamide phosphoribosyltransferase (NAMPT) (Ki = 0.4 nM), causing gradual NAD+ depletion. NAMPT functions as an intra-cellular and extra-cellular NAD biosynthetic enzyme that is important for regulating metabolism and stress resistance through sirtuins and other NAD-consuming regulators. NAD+ depletion by FK-866 directs delayed cell death by apoptosis in Hep-G2 human liver carcinoma cells (IC?? = ~1 nM).

CAS Number: 658084-64-1
Structure Available?: Yes
Salt Form: No
Cell-Permeable?: Yes
PubChem CID: 6914657. Solubility/Reconstitution Instructions: DMSO (>30 mg/ml) and Ethanol
SMILES: C1CN(CCC1CCCCNC(=O)C=CC2=CN=CC=C2)C(=O)C3=CC=CC=C3
InChi: InChI=1S/C24H29N3O2/c28-23(12-11-21-8-6-15-25-19-21)26-16-5-4-7-20-13-17-27(18-14-20)24(29)22-9-2-1-3-10-22/h1-3,6,8-12,15,19-20H,4-5,7,13-14,16-18H2,(H,26,28)/b12-11+
InChi Key: KPBNHDGDUADAGP-VAWYXSNFSA-N
Handling: Protect from light and air.
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