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Chk2 Inhibitor biochemical product blog

Posted on 2015-09-18 09:24:16 by mybiosource_staff
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Tags: Biochemical; Chk2 Inhibitor; Chk2 Inhibitor biochemical;
The Chk2 Inhibitor n/a (Catalog #MBS841968) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase.

To buy or view more detailed product information and pricing, please click on the technical datasheet page below:

Please refer to the product datasheet for known applications of a given biochemical. We\'ve tested the Chk2 Inhibitor with the following immunoassay(s):
Structure Chk2 Inhibitor.

Background: A cell-permeable, potent, and ATP-competitive inhibitor of Chk2 (checkpoint kinase 2; IC?? = 15 nM; Ki = 37 nM). Displays ~1,000-fold greater selectivity for Chk2 compared to Cdk1/cyclin B and CK1 (IC?? = 12 uM and 17 uM, respectively) and only weakly affects the activities of a panel of 31 kinases (< 25% inhibition at 10 uM), including Chk1. Shown to rescue both peripheral CD4+ and CD8+ T-cells from gamma-irradiation-induced apoptosis with an EC?? of 3 uM and 7.6 uM, respectively.

CAS Number: 516480-79-8
Structure Available?: Yes
Salt Form: No
Cell-Permeable?: Yes
MDL Number: MFCD08276917
PubChem CID: 9969021. Solubility/Reconstitution Instructions: DMSO (10 mg/ml)
SMILES: C1=CC(=CC=C1C2=NC3=C(N2)C=C(C=C3)C(=O)N)OC4=CC=C(C=C4)Cl
InChi: InChI=1S/C20H14ClN3O2/c21-14-4-8-16(9-5-14)26-15-6-1-12(2-7-15)20-23-17-10-3-13(19(22)25)11-18(17)24-20/h1-11H,(H2,22,25)(H,23,24)
Handling: Protect from air and moisture.
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