|The Chk2 Inhibitor n/a (Catalog #MBS841968) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase.
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Please refer to the product datasheet for known applications of a given biochemical. We\'ve tested the Chk2 Inhibitor with the following immunoassay(s):
Background: A cell-permeable, potent, and ATP-competitive inhibitor of Chk2 (checkpoint kinase 2; IC?? = 15 nM; Ki = 37 nM). Displays ~1,000-fold greater selectivity for Chk2 compared to Cdk1/cyclin B and CK1 (IC?? = 12 uM and 17 uM, respectively) and only weakly affects the activities of a panel of 31 kinases (< 25% inhibition at 10 uM), including Chk1. Shown to rescue both peripheral CD4+ and CD8+ T-cells from gamma-irradiation-induced apoptosis with an EC?? of 3 uM and 7.6 uM, respectively.
CAS Number: 516480-79-8
Structure Available?: Yes
Salt Form: No
MDL Number: MFCD08276917
PubChem CID: 9969021. Solubility/Reconstitution Instructions: DMSO (10 mg/ml)
InChi Key: UXGJAOIJSROTTN-UHFFFAOYSA-N
Handling: Protect from air and moisture.