|The Bortezomib, Free Base n/a (Catalog #MBS6068966) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase.
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Bortezomib is the active ingredient in the drug sold under the trade name Velcade®. This drug has been approved in at least one country to treat multiple myeloma. It is a potent (Ki, 0.6nM), specific and reversible proteasome inhibitor. There is not any significant inhibitory activity against other enzymes or receptors. In a study with the National Cancer Institute\'s panel of 60 human cell lines, Bortezomib showed a mean IC50 of 7nM as tested by SRB analysis.
CAS Number: 179324-69-7
Molecular Formula: C19H25BN4O4. Melting Point: As reported
Solubility: Soluble in DMSO at 200mg/ml. Soluble in ethanol at 200mg/ml. Very poorly soluble in water. Maximum solubility in plain water is estimated to be about 5-10uM.