beta-Lapachone biochemical product blog
Tags: Biochemical; beta-Lapachone; beta-Lapachone biochemical;
The beta-Lapachone n/a (Catalog #MBS842392) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase.To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given biochemical. We\'ve tested the beta-Lapachone with the following immunoassay(s):
Structure
Background: Cell-permeable. A DNA topoisomerase I inhibitor. Unlike Camptothecin, beta-lapachone does not stabilize the cleavable complex, indicating a novel mode of action. Induces apoptosis in HL-60 and human prostate cancer cells via a p53-independent mechanism and blocks the cell cycle at G0/G1. Also acts as a histone demethylase inhibitor selective to JMJ2DE (IC?? =3.6 uM).
CAS Number: 4707-32-8
Structure Available?: Yes
Salt Form: No
Cell-Permeable?: Yes
MDL Number: MFCD01712233
PubChem CID: 3885. Solubility/Reconstitution Instructions: DMSO (100 mM) or EtOH (50 mM)
SMILES: CC1(CCC2=C(O1)C3=CC=CC=C3C(=O)C2=O)C
InChi: InChI=1S/C15H14O3/c1-15(2)8-7-11-13(17)12(16)9-5-3-4-6-10(9)14(11)18-15/h3-6H,7-8H2,1-2H3
InChi Key: QZPQTZZNNJUOLS-UHFFFAOYSA-N
Handling: Protect from light and mositure.