Altiratinib biochemical product blog
Tags: Biochemical; Altiratinib; Altiratinib biochemical;
The Altiratinib n/a (Catalog #MBS845743) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase.To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given biochemical. We\'ve tested the Altiratinib with the following immunoassay(s):
Structure
Altiratinib is a selective and�highly potent inhibitor of MET; TIE2; VEGFR2 and TRK kinases with potential anticancer activity. It effectively reduces tumor burden in vivo and blocks c-MET pTyr (1349)-mediated signaling; cell growth and migration as compared with a HGF antagonist in vitro.�Through its balanced inhibitory potency versus MET; TIE2; and VEGFR2; altiratinib inhibits three major evasive (re) vascularization and resistance pathways (HGF; ANG; and VEGF) and blocks tumor invasion and metastasis. Displays blood-brain barrier penetration.
Salt Form: No
Molecular Formula: C26H21F3N4O4
CAS Number: 1345847-93-9. Cell-Permeable: Yes
Reconstitution: DMSO (>30 mg/ml)
SMILES: C1CC1C(=O)NC2=NC=CC(=C2)OC3=C(C=C(C(=C3)F)NC(=O)C4(CC4)C(=O)NC5=CC=C(C=C5)F)F
InChi: InChI=1S/C26H21F3N4O4/c27-15-3-5-16(6-4-15)31-24(35)26(8-9-26)25(36)32-20-12-19(29)21(13-18(20)28)37-17-7-10-30-22(11-17)33-23(34)14-1-2-14/h3-7,10-14H,1-2,8-9H2,(H,31,35)(H,32,36)(H,30,33,34)
InChi Key: GNNDEPIMDAZHRQ-UHFFFAOYSA-N.