8- (6- Aminohexylamino)adenosine- 3', 5'- cyclic monophosphorothioate, Rp- isomer, immobilized on agarose gel (Rp-8-AHA-cAMPS-Agarose) biochemical product blog
Tags: Biochemical;
The 8- (6- Aminohexylamino)adenosine- 3\', 5\'- cyclic monophosphorothioate, Rp- isomer, immobilized on agarose gel (Rp-8-AHA-cAMPS-Agarose) n/a (Catalog #MBS256483) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase.To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given biochemical. We\'ve tested the 8- (6- Aminohexylamino)adenosine- 3\', 5\'- cyclic monophosphorothioate, Rp- isomer, immobilized on agarose gel (Rp-8-AHA-cAMPS-Agarose) with the following immunoassay(s):
Structure
The metabolically stable protein kinase An inhibitor Rp-cAMPS immobilized on agarose by an aminohexylamino spacer attached to position 8 of the ligand. Free Rp-cAMPS binds to the protein kinase A holoenzyme but prevents dissociation of catalytic and regulatory subunits. In addition it is not hydrolized by mammalian phosphodiesterases. The gel can be used for affinity chromatography of various cyclic nucleotide-responsive proteins such as protein kinase A (presumably as its holoenzyme), phosphodiesterases and others. This ligand is offered with a shorter spacer (Rp-8-AEA-cAMPS-Agarose) as well. Detailed technical information available. References: Margarucci et al., Mol. BioSyst., 7, 2311 - 2319 (2011); Bertinetti et al., BMC Chem Biol, 9 (2009).
Normally all affinity gels are supplied in pre-packed columns. The free beads without a column are available upon request..