|The 2\'- O- (6- Aminohexylcarbamoyl)guanosine- 3\', 5\'- cyclic monophosphorothioate, Sp- isomer, immobilized on agarose gel (Sp-2\'-AHC-cGMPS-Agarose) n/a (Catalog #MBS256365) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase.
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Please refer to the product datasheet for known applications of a given biochemical. We\'ve tested the 2\'- O- (6- Aminohexylcarbamoyl)guanosine- 3\', 5\'- cyclic monophosphorothioate, Sp- isomer, immobilized on agarose gel (Sp-2\'-AHC-cGMPS-Agarose) with the following immunoassay(s):
The PDE-resistant PKG activator Sp-cGMPS immobilized on agarose by an aminohexylcarbamoyl spacer attached to the ribose 2\'-position of the ligand. The gel can be used for affinity chromatography of various cyclic nucleotide-responsive proteins, especially those which tolerate modification of the 2\'-ribose hydroxyl group such as some phosphodiesterases. This type of gel is also offered with normal cGMP (2\'-AHC-cGMP-Agarose). Detailed technical information available. Compare: Corrie et al., Prot. Expr. Purif., 3, 417 - 420 (1992).
Normally all affinity gels are supplied in pre-packed columns. The free beads without a column are available upon request..