2'- O- (2- Aminoethylcarbamoyl)adenosine- 3', 5'- cyclic monophosphorothioate, Sp- isomer, immobilized on agarose gel (Sp-2'-AEC-cAMPS-Agarose) biochemical product blog
Tags: Biochemical;
The 2\'- O- (2- Aminoethylcarbamoyl)adenosine- 3\', 5\'- cyclic monophosphorothioate, Sp- isomer, immobilized on agarose gel (Sp-2\'-AEC-cAMPS-Agarose) n/a (Catalog #MBS256412) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase.To buy or view more detailed product information and pricing, please click on the technical datasheet page below:
Please refer to the product datasheet for known applications of a given biochemical. We\'ve tested the 2\'- O- (2- Aminoethylcarbamoyl)adenosine- 3\', 5\'- cyclic monophosphorothioate, Sp- isomer, immobilized on agarose gel (Sp-2\'-AEC-cAMPS-Agarose) with the following immunoassay(s):
Structure
The protein kinase An activator Sp-cAMPS immobilized on agarose by an aminoethylcarbamoyl spacer attached to the ribose 2\' position of the ligand. Free Sp-cAMPS is only very slowly metabolized by mammalian phosphodiesterases and thus represents an extraordinary stable ligand. In addition, its reduced binding affinity towards protein kinase A compared to cAMP results in milder desorption conditions in affinity chromatography. The gel can be used for affinity chromatography of various cyclic nucleotide-responsive proteins, especially those which tolerate modification of the 2\'-ribose hydroxyl group such as some phosphodiesterases. This type of gel is offered with a longer spacer (Sp-2\'-AHC-cAMPS-Agarose) as well. Detailed technical information available.
Normally all affinity gels are supplied in pre-packed columns. The free beads without a column are available upon request..